Secondary Metabolites from Andrographis paniculata

Hepatoprotective Diterpenoids Isolated from Andrographis paniculata

Andrographis paniculata (Burm.f.) Nees (Acanthaceae), a plant widely used as traditional herbal medicine in many countries, has drawn attention of the researchers in recent years. Its major constituents are diterpenoids and flavonoids. This article reviews the anti-hepatotoxic effects of A. paniculata extract and derivative compounds, such as andrographolide, the major active compound, most stu...

Andrographolide isolated from Andrographis paniculata Ness

Andrographolide isolated from Andrographis paniculata Ness (A and 1.40 mM induced DNA fragmentation and increased the percentage o breast cancer cell line was treated for 24 , 48 and 72 h. The results de induce apoptosis in TD-47 human breast cancer cell line in a time and increase expression of p53, bax , caspase-3 and decrease ex immunohistochemical analysis.

Bisandrographolide from Andrographis paniculata activates TRPV4 channels.

Many transient receptor potential (TRP) channels are activated or blocked by various compounds found in plants; two prominent examples include the activation of TRPV1 channels by capsaicin and the activation of TRPM8 channels by menthol. We sought to identify additional plant compounds that are active on other types of TRP channels. We screened a library of extracts from 50 Chinese herbal plant...

Assessment report on Andrographis paniculata Nees, folium

Perspective of Andrographis paniculata in Neurological Disorders

Andrographis paniculata (Burm. F.) Wall. Ex Nees (family Acanthaceae) also known as Kalmegh (Figure 1), is extremely bitter in taste and it is often referred to as the “the king of bitters”. This plant has been used as bitter tonic, stimulant, and aperients in Ayurvedic and other traditionally known health care systems widely practiced in India and other Asiatic countries. Amongst numerous plan...